Benzamide, 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-
KKL-35
CAS: 865285-29-6
Molecular Formula: C15H9ClFN3O2
Benzamide, 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]- - Names and Identifiers
| Name | KKL-35 |
| Synonyms | SRJ-23 KKL-35 KKL-35(KKL 35 4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-benzamide Benzamide, 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]- |
| CAS | 865285-29-6 |
Benzamide, 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]- - Physico-chemical Properties
| Molecular Formula | C15H9ClFN3O2 |
| Molar Mass | 317.7 |
| Solubility | DMSO |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | Sealed in dry,2-8°C |
| In vitro study | KKL-35 exhibits broad-spectrum antibiotic activity. KKL-35 prevents growth of B. anthracis and M. smegmatis with minimum inhibitory concentration (MIC) values of less than 6 µM. KKL-35 inhibit trans-translation at some step before proteolysis of tagged proteins. KKL-35 inhibits tagging of DHFR-ns. A large amount of untagged DHFR is produced in reactions with the highest concentrations of KKL-35, indicating that KKL-35 does not inhibit translation. KKL-35 prevents growth of WT S. flexneri with a MIC of 6 µM, and addition of KKL-35 to a growing culture of S. flexneri stops growth. In an S. flexneri strain expressing ArfA and deleted for ssrA, addition of KKL-35 has little effect on viability or growth rate. KKL-35 inhibits the growth of E. coli ∆tolC, which is deficient in small molecule efflux, with an MIC of 0.3 µM. |
| In vivo study | Evidence suggest that the in vivo effects of KKL-35 are caused by inhibition of the release of nonstop translation complexes by trans-translation. KKL-35 inhibits trans-translation and prevents growth of S. flexneri strains that require trans-translation. The correlation between inhibition of trans-translation and growth is supported by genetic and pharmacological experiments showing that alternative mechanisms to release nonstop translation complexes relieve the growth suppression of KKL-35. |
Benzamide, 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]- - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
Benzamide, 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.148 ml | 15.738 ml | 31.476 ml |
| 5 mM | 0.63 ml | 3.148 ml | 6.295 ml |
| 10 mM | 0.315 ml | 1.574 ml | 3.148 ml |
| 5 mM | 0.063 ml | 0.315 ml | 0.63 ml |
Last Update：2024-01-02 23:10:35
Benzamide, 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]- - Reference Information
| biological activity | KKL-35 inhibition of trans-translation tagging reaction with IC50 of 0.9 μm. It has broad-spectrum antibiotic activity. |
| Target | IC50: 0.9 µm (trans -translation tagging reaction) |
Last Update：2024-04-09 21:11:58
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Spot supply
Product Name: KKL-35 Visit Supplier Webpage Request for quotationCAS: 865285-29-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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